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1

Creation of nano eye-drops and effective drug delivery to the interior of the eye

Ikuta, Yoshikazu, Aoyagi, Shigenobu, Tanaka, Yuji, Sato, Kota, Inada, Satoshi, Koseki, Yoshitaka, Onodera, Tsunenobu, Oikawa, Hidetoshi, Kasai, Hitoshi

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.21 MB

english, 2017

2

Design of Novel Hydrogen-Bonding Donor Organocatalysts and Their Application to Asymmetric Direct Aldol Reaction

Akutsu, Hiroshi, Nakashima, Kosuke, Yanai, Hikaru, Kotani, Akira, Hirashima, Shin-ichi, Yamamoto, Tomoyuki, Takahashi, Ryuta, Yoshida, Akihiro, Koseki, Yuji, Hakamata, Hideki, Matsumoto, Takashi, Miur

Journal:

Year:

2017

Language:

english

File:

PDF, 196 KB

english, 2017

3

Total Synthesis of Lennoxamine (Ia) and Chilenine (Ib) via Ring-Expansion of Isoindoloisoquinoline to Isoindolobenzazepine.

Yuji Koseki, Shinya Katsura, Shuichi Kusano, Harumi Sakata, Hiroto Sato, Yoshinori Monzene, Tatsuo Nagasaka

Journal:

Year:

2003

File:

PDF, 63 KB

2003

4

Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication

Shibutani, Toshihiro, Ito, Shinsuke, Toda, Mariko, Kanao, Rie, Collins, Leonard B., Shibata, Marika, Urabe, Miho, Koseki, Haruhiko, Masuda, Yuji, Swenberg, James A., Masutani, Chikahide, Hanaoka, Fumi

Journal:

Scientific Reports

Year:

2014

Language:

english

File:

PDF, 4.51 MB

english, 2014

5

Poly(ethylene glycol)–poly(lysine) block copolymer–ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells

Toshiyama, Reishi, Konno, Masamitsu, Eguchi, Hidetoshi, Takemoto, Hiroyasu, Noda, Takehiro, Asai, Ayumu, Koseki, Jun, Haraguchi, Naotsugu, Ueda, Yuji, Matsushita, Katsunori, Asukai, Kei, Ohashi, Tomof

Journal:

Year:

2018

Language:

english

File:

PDF, 5.85 MB

english, 2018

6

Boundary Element Method Analysis of Interdigital Transducers Having Arbitrary Metallisation Ratio

Hashimoto, Ken-ya, Koseki, Yuji, Yamaguchi, Masatsune

Journal:

Japanese Journal of Applied Physics

Year:

1991

File:

PDF, 431 KB

1991

7

ChemInform Abstract: A new Approach to Isoindolobenzazepines via a Ring-Expansion of Isoindoloisoquinoline: Synthesis of Lennoxamine and Chilenine.

Yuji Koseki, Shuichi Kusano, Harumi Sakata, Tatsuo Nagasaka

Journal:

Year:

1999

File:

PDF, 36 KB

1999

8

ChemInform Abstract: Silver Salt Promoted Direct Cross-Coupling Reactions of Alkynylsilanes with Aryl Iodides: Synthesis of Aryl-Substituted Alkynylamides.

Yuji Koseki, Kunio Omino, Shinobu Anzai, Tatsuo Nagasaka

Journal:

Year:

2000

File:

PDF, 31 KB

2000

9

ChemInform Abstract: Stereoselective Synthesis of 5-(1-Hydroxyalkyl)-2-pyrrolidinones Utilizing Oxidation of 5-Alkylidene-2-pyrrolidinones to Acyliminium Ion Precursors.

Yuji Koseki, Shuichi Kusano, Daisuke Ichi, Keiji Yoshida, Tatsuo Nagasaka

Journal:

Year:

2001

Language:

english

File:

PDF, 42 KB

english, 2001

10

ChemInform Abstract: A Formal Total Synthesis of (.+-.)-Cephalotaxine (I) Using Sequential N-Acyliminium Ion Reactions.

Yuji Koseki, Hiroto Sato, Yumi Watanabe, Tatsuo Nagasaka

Journal:

Year:

2002

File:

PDF, 28 KB

2002

11

Synthesis of Optically Active Tetrahydro-3-benzazepine-2-carboxylic Acid Derivatives via the Ring Expansion Reaction of Isoquinolines and Enzymatic Resolution.

Yuji Koseki, Hidefumi Ozawa, Katsuaki Kitahara, Ichiro Kato, Hiroto Sato, Haruhiko Fukaya, Tatsuo Nagasaka

Journal:

Year:

2004

File:

PDF, 109 KB

2004

12

Identification of novel potential antibiotics for tuberculosis by in silico structure-based drug screening

Yuya Izumizono, Shiho Arevalo, Yuji Koseki, Masato Kuroki, Shunsuke Aoki

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.01 MB

english, 2011

13

Identification of succinate exporter in Corynebacterium glutamicum and its physiological roles under anaerobic conditions

Keita Fukui, Chie Koseki, Yoko Yamamoto, Jun Nakamura, Ayako Sasahara, Reiko Yuji, Kenichi Hashiguchi, Yoshihiro Usuda, Kazuhiko Matsui, Hiroyuki Kojima, Keietsu Abe

Journal:

Journal of Biotechnology

Year:

2011

Language:

english

File:

PDF, 611 KB

english, 2011

14

The intramolecular tandem Michael/Mannich-type reaction of α,β-unsaturated carbonyl compounds with acyliminium ions provides access to chiral indolizidines

Yuji Koseki, Koji Fujino, Ai Takeshita, Hiroto Sato, Tatsuo Nagasaka

Journal:

Tetrahedron: Asymmetry

Year:

2007

Language:

english

File:

PDF, 220 KB

english, 2007

15

Stereoselective Synthesis of 5-(1-Hydroxyalkyl)-2-pyrrolidinones Utilizing Oxidation of 5-Alkylidene-2-pyrrolidinones to Acyliminium Ion Precursors

Yuji Koseki, Shuichi Kusano, Daisuke Ichi, Keiji Yoshida, Tatsuo Nagasaka

Journal:

Year:

2000

Language:

english

File:

PDF, 206 KB

english, 2000

16

Silver salt-promoted direct cross-coupling reactions of alkynylsilanes with aryl iodides: synthesis of aryl-substituted alkynylamides

Yuji Koseki, Kunio Omino, Shinobu Anzai, Tatsuo Nagasaka

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 116 KB

english, 2000

17

Stereoselective synthesis of tilivalline

Tatsuo Nagasaka, Yuji Koseki, Fumiko Hamaguchi

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 143 KB

english, 1989

18

Intramolecular Cyclization of β-Alkynylpropanamides to γ-Alkylidene-γ-butyrolactams

Yuji Koseki, Shuichi Kusano, Tatsuo Nagasaka

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 220 KB

english, 1998

19

A new approach to isoindolobenzazepines via a ring-expansion of isoindoloisoquinoline: Synthesis of lennoxamine and chilenine

Yuji Koseki, Shuichi Kusano, Harumi Sakata, Tatsuo Nagasaka

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 217 KB

english, 1999

20

Microvolt T Wave Alternans in Human Cardiac Hypertrophy: Electrical Instability and Abnormal Myocardial Arrangement

YUJI KON-NO, JUN WATANABE, YOSHITO KOSEKI, JIRO KOYAMA, AKI YAMADA, SUNAO TODA, TSUYOSHI SHINOZAKI, MITSUMASA FUKUCHI, MASAHITO MIURA, YUTAKA KAGAYA, KUNIO SHIRATO

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2001

Language:

english

File:

PDF, 303 KB

english, 2001

21

Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1

Daisuke Minehira, Daisuke Takeda, Hirokazu Urata, Atsushi Kato, Isao Adachi, Xu Wang, Yuji Matsuya, Kenji Sugimoto, Mayuko Takemura, Satoshi Endo, Toshiyuki Matsunaga, Akira Hara, Jun Koseki, Kayo Nar

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.07 MB

english, 2012

22

Aberrant structures of Parkinson’s disease-associated ubiquitin C-terminal hydrolase L1 predicted by molecular dynamics

Yuji Koseki, Tomohiro Kinjo, Masato Kuroki, Shunsuke Aoki

Journal:

Chemical Physics Letters

Year:

2012

Language:

english

File:

PDF, 1.55 MB

english, 2012

23

Factors associated with dry mouth in dependent Japanese elderly

Naoki Kakudate, Tsukasa Muramatsu, Mami Endoh, Kazuhito Satomura, Takeyoshi Koseki, Yuji Sato, Kayoko Ito, Tadashi Ogasawara, Seiji Nakamura, Etsuo Kishimoto, Haruhiko Kashiwazaki, Yoshihisa Yamashita

Journal:

Year:

2012

Language:

english

File:

PDF, 104 KB

english, 2012

24

Comparative assessment of cardiovascular regulation and sympathetic skin response to lower body negative pressure in NIDDM

Jiro Koyama, Yoshito Koseki, Takuro Tashima, Yuji Konno, Aki Yamada, Jun Watanabe, Kunio Shirato

Journal:

Journal of Cardiac Failure

Year:

1998

Language:

english

File:

PDF, 63 KB

english, 1998

25

Identification of Compounds with Potential Antibacterial Activity against Mycobacterium through Structure-Based Drug Screening

Kinjo, Tomohiro, Koseki, Yuji, Kobayashi, Maiko, Yamada, Atsumi, Morita, Koji, Yamaguchi, Kento, Tsurusawa, Ryoya, Gulten, Gulcin, Komatsu, Hideyuki, Sakamoto, Hiroshi, Sacchettini, James C., Kitamura

Journal:

Journal of Chemical Information and Modeling

Year:

2013

Language:

english

File:

PDF, 2.13 MB

english, 2013

26

Asymmetric conjugate addition of aldehydes to vinyl sulfone using a diaminomethylenemalononitrile organocatalyst

Kanada, Yohei, Yuasa, Hiroki, Nakashima, Kosuke, Murahashi, Miho, Tada, Norihiro, Itoh, Akichika, Koseki, Yuji, Miura, Tsuyoshi

Journal:

Tetrahedron Letters

Year:

2013

Language:

english

File:

PDF, 1.47 MB

english, 2013

27

Identification of novel antimycobacterial chemical agents through the in silico multi-conformational structure-based drug screening of a large-scale chemical library

Koseki, Yuji, Kinjo, Tomohiro, Kobayashi, Maiko, Aoki, Shunsuke

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 949 KB

english, 2013

28

Identification of a novel chemical inhibitor for NGF by virtual screening

Shibata, Takahiro, Koseki, Yuji, Kuroki, Masato, Tsuruta, Kouichrou, Arevalo, Shiho, Aoki, Shunsuke

Journal:

Neuroscience Research

Year:

2010

Language:

english

File:

PDF, 74 KB

english, 2010

29

The relationship between positive and negative automatic thought and activity in the prefrontal and temporal cortices: A multi-channel near-infrared spectroscopy (NIRS) study

Koseki, Shunsuke, Noda, Takamasa, Yokoyama, Satoshi, Kunisato, Yoshihiko, Ito, Daisuke, Suyama, Haruna, Matsuda, Taro, Sugimura, Yuji, Ishihara, Naoko, Shimizu, Yu, Nakazawa, Kanako, Yoshida, Sumiko,

Journal:

Journal of Affective Disorders

Year:

2013

Language:

english

File:

PDF, 2.16 MB

english, 2013

30

Endoscopy-guided laser lithotripsy for a difficult-to-crush enterolith

Nishikawa, Takao, Tsuyuguchi, Toshio, Ohyama, Hiroshi, Watanabe, Yuto, Koseki, Hirotaka, Sakai, Yuji, Sugiyama, Harutoshi, Sakamoto, Dai, Kiyono, Soichiro, Nakamura, Masato, Yokosuka, Osamu

Journal:

Gastrointestinal Endoscopy

Year:

2014

Language:

english

File:

PDF, 234 KB

english, 2014

31

Pyrrolidine-diaminomethylenemalononitrile organocatalyst for Michael additions of carbonyl compounds to nitroalkenes under solvent-free conditions

Nakashima, Kosuke, Hirashima, Shin-ichi, Kawada, Masahiro, Koseki, Yuji, Tada, Norihiro, Itoh, Akichika, Miura, Tsuyoshi

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 1.98 MB

english, 2014

32

Solvent-free asymmetric conjugate addition of malonates to enones using a diaminomethylenemalononitrile organocatalyst

Hirashima, Shin-ichi, Sakai, Takaaki, Nakashima, Kosuke, Watanabe, Nana, Koseki, Yuji, Mukai, Kanako, Kanada, Yohei, Tada, Norihiro, Itoh, Akichika, Miura, Tsuyoshi

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 2.80 MB

english, 2014

33

Cinchona–diaminomethylenemalononitrile organocatalyst for asymmetric conjugate addition of 1,3-diketone to nitroalkene

Hirashima, Shin-ichi, Nakashima, Kosuke, Fujino, Yuki, Arai, Ryoga, Sakai, Takaaki, Kawada, Masahiro, Koseki, Yuji, Murahashi, Miho, Tada, Norihiro, Itoh, Akichika, Miura, Tsuyoshi

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 1.42 MB

english, 2014

34

Asymmetric conjugate addition of malonate to α,β-unsaturated ketones in water using a perfluoroalkanesulfonamide organocatalyst

Kamito, Yuji, Masuda, Akira, Yuasa, Hiroki, Tada, Norihiro, Itoh, Akichika, Nakashima, Kosuke, Hirashima, Shin-ichi, Koseki, Yuji, Miura, Tsuyoshi

Journal:

Tetrahedron: Asymmetry

Year:

2014

Language:

english

File:

PDF, 4.02 MB

english, 2014

35

Molecular Dynamics Studies of the Structural Change in 1,3-Diamino-2,4,6-trinitrobenzene (DATB) in the Crystalline State under High Pressure

Kohno, Yuji, Hiyoshi, Reiko I., Yamaguchi, Yoshitaka, Matsumoto, Shinya, Koseki, Atsushi, Takahashi, Osamu, Yamasaki, Katsuyoshi, Ueda, Kazuyoshi

Journal:

Journal of Physical Chemistry A

Year:

2009

Language:

english

File:

PDF, 1.95 MB

english, 2009

36

Stereoselective Synthesis of Tilivalline 1

Nagasaka, Tatsuo, Koseki, Yuji

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 80 KB

english, 1998

37

Identification of Novel Potential Antibiotics against Staphylococcus Using Structure-Based Drug Screening Targeting Dihydrofolate Reductase

Kobayashi, Maiko, Kinjo, Tomohiro, Koseki, Yuji, Bourne, Christina R., Barrow, William W., Aoki, Shunsuke

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 3.27 MB

english, 2014

38

A Formal Total Synthesis of (±)-Cephalotaxine Using Sequential N -Acyliminium Ion Reactions

Koseki, Yuji, Sato, Hiroto, Watanabe, Yumi, Nagasaka, Tatsuo

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 65 KB

english, 2002

39

ChemInform Abstract: Pyrrolidine-Diaminomethylenemalononitrile Organocatalyst for Michael Additions of Carbonyl Compounds to Nitroalkenes under Solvent-Free Conditions.

Nakashima, Kosuke, Hirashima, Shin-ichi, Kawada, Masahiro, Koseki, Yuji, Tada, Norihiro, Itoh, Akichika, Miura, Tsuyoshi

Journal:

Year:

2014

File:

PDF, 23 KB

2014

40

Pyrrolidine–diaminomethylenemalononitrile organocatalyst for solvent-free asymmetric direct aldol reactions

Nakashima, Kosuke, Hirashima, Shin-ichi, Akutsu, Hiroshi, Koseki, Yuji, Tada, Norihiro, Itoh, Akichika, Miura, Tsuyoshi

Journal:

Tetrahedron Letters

Year:

2015

Language:

english

File:

PDF, 2.41 MB

english, 2015

41

Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach

Kanetaka, Hironori, Koseki, Yuji, Taira, Junichi, Umei, Tomohiro, Komatsu, Hideyuki, Sakamoto, Hiroshi, Gulten, Gulcin, Sacchettini, James C., Kitamura, Mitsuru, Aoki, Shunsuke

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.69 MB

english, 2015

42

Asymmetric Conjugate Addition of Ketones to Maleimides Using Diaminomethyleneindenedione Organocatalyst

Nakashima, Kosuke, Kawada, Masahiro, Hirashima, Shin-ichi, Kato, Mana, Koseki, Yuji, Miura, Tsuyoshi

Journal:

Year:

2015

Language:

english

File:

PDF, 197 KB

english, 2015

43

[IEEE 2014 IEEE International Conference on Service Operations and Logistics, and Informatics (SOLI) - Qingdao, China (2014.10.8-2014.10.10)] Proceedings of 2014 IEEE International Conference on Service Operations and Logistics, and Informatics - A financial risk evaluation service for integrating private portfolios securely

Watanabe, Yuji, Koseki, Akira

Year:

2014

Language:

english

File:

PDF, 621 KB

english, 2014

44

MP33-01 RISK FACTORS FOR FEBRILE URINARY TRACT INFECTION AFTER URETEROSCOPIC STONE REMOVAL

Kato, Yuji, Koseki, Tatsuro, Mastsutani, Ryo, Sasao, Takumi, Wada, Hideki, Yamazaki, Kiyohito, Saka, Taketoshi

Journal:

The Journal of Urology

Year:

2016

Language:

english

File:

PDF, 39 KB

english, 2016

45

ChemInform Abstract: Asymmetric Conjugate Addition of Malonate to α,β-Unsaturated Ketones in Water Using a Perfluoroalkanesulfonamide Organocatalyst.

Kamito, Yuji, Masuda, Akira, Yuasa, Hiroki, Tada, Norihiro, Itoh, Akichika, Nakashima, Kosuke, Hirashima, Shin-ichi, Koseki, Yuji, Miura, Tsuyoshi

Journal:

Year:

2015

File:

PDF, 87 KB

2015

46

Determination of serum brassicasterol in spontaneously hypertensive rats stroke-prone fed a high-ergosterol diet by ultra performance liquid chromatography

Ohtsubo, Takaaki, Kageyama, Ryo, Koseki, Yuji, Hagi, Junya, Kotani, Akira, Yamamoto, Kazuhiro, Kusu, Fumiyo, Miura, Tsuyoshi, Hakamata, Hideki

Journal:

European Journal of Lipid Science and Technology

Year:

2015

Language:

english

File:

PDF, 1.24 MB

english, 2015

47

Asymmetric Hydrophosphonylation of Aldehydes using a Cinchona -Diaminomethylenemalononitrile Organocatalyst

Hirashima, Shin-ichi, Arai, Ryoga, Nakashima, Kosuke, Kawai, Nobuaki, Kondo, Junko, Koseki, Yuji, Miura, Tsuyoshi

Journal:

Advanced Synthesis & Catalysis

Year:

2015

Language:

english

File:

PDF, 483 KB

english, 2015

48

ChemInform Abstract: Asymmetric Conjugate Addition of Aldehydes to Vinyl Sulfone Using a Diaminomethylenemalononitrile Organocatalyst.

Kanada, Yohei, Yuasa, Hiroki, Nakashima, Kosuke, Murahashi, Miho, Tada, Norihiro, Itoh, Akichika, Koseki, Yuji, Miura, Tsuyoshi

Journal:

Year:

2013

File:

PDF, 29 KB

2013

49

ChemInform Abstract: Asymmetric Conjugate Addition of Malonates to Enones Using Perfluorobutanesulfonamide Organocatalyst.

Kamito, Yuji, Masuda, Akira, Yuasa, Hiroki, Tada, Norihiro, Itoh, Akichika, Koseki, Yuji, Miura, Tsuyoshi

Journal:

Year:

2014

File:

PDF, 22 KB

2014

50

ChemInform Abstract: Solvent-Free Asymmetric Conjugate Addition of Malonates to Enones Using a Diaminomethylenemalononitrile Organocatalyst.

Hirashima, Shin-ichi, Sakai, Takaaki, Nakashima, Kosuke, Watanabe, Nana, Koseki, Yuji, Mukai, Kanako, Kanada, Yohei, Tada, Norihiro, Itoh, Akichika, Miura, Tsuyoshi

Journal:

Year:

2015

File:

PDF, 20 KB

2015